The U.S. Cluster Mapping Project is led by the Institute for Strategy and Competitiveness at Harvard Business School in partnership with the U.S. Department of Commerce and U.S. Economic Development Administration.

The Institute works with Phase2 Technology, a web technology company based in Alexandria, VA, to design and develop the website that presents all of the data and content for the project.

The Institute collaborates with faculty members from MIT Sloan School of Management, MIT's Entrepreneurship Center, and Fox School of Business at Temple University to conduct research on the role of clusters in regional economic prosperity, and to develop new metrics to assess clusters and regional economies.

From 2010 to 2013, Monitor Group and four organizations in various regions of the United States worked under the Institute's direction to develop case studies on the effective use of clusters in public policy, as well as practical toolkits for cluster-based competitiveness efforts. They also played an important role in connecting the project with the needs of governmental and non-governmental users. These four regional partners are the Humphrey School of Public Affairs at the University of Minnesota, the Innovation Institute at Massachusetts Technology Collaborative, Oregon Business Council, and New Carolina.

The Institute partners with two other EDA-funded website projects to align regional economic data and content. These partners are STATS America, which is run by the Indiana Business Research Center at Indiana University's Kelley School of Business, and RIAN (the Regional Innovation Acceleration Network).